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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...

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Dysrhythmias II: Classification of Tachyarrhythmias

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Related Experiment Video

Updated: May 28, 2026

Robotic Ablation of Atrial Fibrillation

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

Atrial flutter associated with carboplatin administration.

Sammy Zakaria¹, Kit Yu Lu, Veronique Nussenblatt

¹Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA. szakari2@jhmi.edu

The Annals of Pharmacotherapy

|October 20, 2011

Summary

This summary is machine-generated.

This case report suggests a possible link between carboplatin chemotherapy and atrial flutter, a type of heart arrhythmia. Further cardiac monitoring may be needed for patients receiving this treatment.

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Area of Science:

Cardiology
Oncology
Pharmacology

Background:

Chemotherapy, particularly platinum-based compounds like carboplatin, can cause cardiac toxicities.
Atrial flutter is a supraventricular tachyarrhythmia that can lead to significant morbidity.

Observation:

A 69-year-old patient with small cell lung cancer developed atrial flutter during carboplatin infusion.
The arrhythmia spontaneously resolved within 24 hours without other identifiable causes.
The patient had a history of cardiovascular disease and inconsistent medication adherence.

Findings:

The Naranjo probability scale indicated a possible relationship between carboplatin and atrial flutter.
While other platinum compound cardiac events are documented, this is the first reported association with atrial flutter.
The mechanism may involve direct arrhythmogenic effects or a hypersensitivity reaction.

Implications:

This case highlights a potential novel adverse effect of carboplatin.
Cardiac monitoring during carboplatin infusion is recommended for patients with pre-existing cardiac conditions or high cardiac risk.
Reporting this event to the FDA underscores the importance of pharmacovigilance for chemotherapy-induced cardiac arrhythmias.