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Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Updated: May 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

MRSA: the first half century.

Robert C Moellering1

  • 1Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA. rmoeller@bidmc.harvard.edu

The Journal of Antimicrobial Chemotherapy
|October 20, 2011
PubMed
Summary
This summary is machine-generated.

Methicillin-resistant Staphylococcus aureus (MRSA) emerged 50 years ago and continues to challenge medical professionals. This article explores the key factors enabling MRSA

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Last Updated: May 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pathogen Research

Background:

  • Fifty years ago, methicillin-resistant Staphylococcus aureus (MRSA) was first identified.
  • Its emergence prompted significant scientific and medical efforts to control this pathogen.

Observation:

  • Despite extensive efforts, MRSA has become a global health challenge.
  • The pathogen continues to pose significant difficulties for researchers and clinicians.

Findings:

  • This article delves into the primary reasons behind MRSA's success.
  • It examines the factors contributing to its ability to thrive and cause disease.

Implications:

  • Understanding MRSA's resilience is crucial for developing effective treatment strategies.
  • Continued research is vital to combat this persistent infectious threat.