Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
DNA Base Pairing02:27

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

Overview
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a tetracycline-inducible programmed ribosomal frameshifting platform for sensitive regulation of mammalian gene expression.

Nucleic acids research·2026
Same author

Small Molecule-Controlled Gene Expression: Design of Drug-like High-Affinity Modulators of a Custom-Made Riboswitch.

ACS chemical biology·2026
Same author

Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction.

Nature communications·2025
Same author

Indel-driven evolution of the canavanine tRNA-editing deacetylase enzyme CtdA.

Journal of structural biology: X·2025
Same author

Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture.

Nucleic acids research·2025
Same author

Diverse Library of 5a-Substituted Carba-Glucosamines.

The Journal of organic chemistry·2025

Related Experiment Video

Updated: May 28, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

RNA quadruplexes.

Kangkan Halder1, Jörg S Hartig

  • 1Department of Chemistry, University of Konstanz, Universitätsstrasse 10, D-78457 Konstanz, Germany.

Metal Ions in Life Sciences
|October 20, 2011
PubMed
Summary
This summary is machine-generated.

RNA quadruplexes, though less studied than DNA counterparts, are stable, metal-ion-dependent structures. Their formation in cellular RNAs is increasingly suggested, prompting research into their roles.

More Related Videos

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Related Experiment Videos

Last Updated: May 28, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • RNA quadruplexes are four-stranded nucleic acid structures formed from guanosine-rich sequences.
  • While DNA quadruplexes are well-characterized, RNA quadruplexes remain less understood.
  • Unlike double-stranded DNA, single-stranded RNA favors intramolecular folding, making RNA quadruplex formation likely.

Purpose of the Study:

  • To provide an overview of the current understanding of RNA quadruplexes.
  • To summarize key aspects including structures, stabilities, and potential biological roles.
  • To highlight the emerging field of RNA quadruplex research.

Main Methods:

  • Literature review and synthesis of existing research on RNA quadruplexes.
  • Comparative analysis of RNA and DNA quadruplex properties.
  • Discussion of structural and stability data.

Main Results:

  • RNA quadruplexes exhibit stability comparable to DNA quadruplexes.
  • Their formation is dependent on metal ions, similar to DNA.
  • RNA quadruplexes appear to adopt more restricted conformations than DNA quadruplexes.
  • Intramolecular folding is favored in RNA due to the absence of a complementary strand.

Conclusions:

  • RNA quadruplexes are significant structures with potential roles in cellular processes.
  • Further research is needed to fully elucidate their functions and implications.
  • The field of RNA quadruplexes is rapidly developing.