Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protozoan infections.

E U Canning1

  • 1Imperial College of Science, Technology and Medicine, London, UK.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Patients with acquired immune deficiency syndrome (AIDS) face severe protozoan infections like toxoplasmosis and cryptosporidiosis due to T cell depletion. Early detection and prevention are crucial for managing these opportunistic infections in immunocompromised individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructure of Encephalitozoon sp. infecting the conjunctival, corneal and nasal epithelia of a patient with AIDS.

European journal of protistology·2012
Same author

A light- and electron-microscopic study of Amblyospora egypti n.sp. infecting Culex pipiens in Egypt.

European journal of protistology·2012
Same author

Myositis due to the microsporidian Anncaliia (Brachiola) algerae in a lung transplant recipient.

Transplant infectious disease : an official journal of the Transplantation Society·2012
Same author

The Case for Naming Actinosporeans using the Zoological Code.

Parasitology today (Personal ed.)·2006
Same author

Experimental infection of severe combined immunodeficient (SCID) mice with the human microsporidian Trachipleistophora hominis.

Parasitology·2004
Same author

Small subunit ribosomal DNA phylogeny of microsporidia that infect Daphnia (Crustacea: Cladocera).

Parasitology·2002

Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Protozoan infections are often T cell-mediated, leading to severe outcomes in individuals with acquired immune deficiency syndrome (AIDS).
  • Toxoplasmosis and cryptosporidiosis are common protozoan infections in AIDS patients, frequently arising from latent infections or new exposures.
  • Depletion of T-helper (CD4+) lymphocytes in AIDS patients compromises the immune response against these pathogens.

Purpose of the Study:

  • To highlight the increased severity and commonality of protozoan infections in AIDS patients.
  • To explain the mechanisms by which T cell depletion exacerbates these infections.
  • To provide guidance on preventing and managing toxoplasmosis and cryptosporidiosis in AIDS patients.

Main Methods:

Related Experiment Videos

  • Review of existing literature on protozoan infections in immunocompromised individuals.
  • Analysis of the immunological mechanisms underlying severe outcomes in AIDS patients.
  • Identification of transmission routes and risk factors for toxoplasmosis and cryptosporidiosis.

    • Main Results:

    • Cerebral toxoplasmosis in AIDS patients often results from reactivation of latent infections, leading to necrotizing encephalitis.
    • Primary toxoplasmosis infections can become systemic in AIDS patients, particularly those with low CD4+ counts and negative Toxoplasma antibodies.
    • Cryptosporidiosis in AIDS patients typically presents as a primary infection, causing severe secretory diarrhea with limited treatment options.

    Conclusions:

    • AIDS patients are highly susceptible to severe protozoan infections, necessitating stringent preventive measures.
    • Avoiding exposure to cats and undercooked meat is critical for preventing toxoplasmosis.
    • Minimizing risks from contaminated water, other people, and animals is essential for preventing cryptosporidiosis in AIDS patients.