Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dually Charged Dendrimeric Polyglycerol Modulates Interleukin-33 at Alarmin Receptors in Microglia.

ACS chemical neuroscience·2026
Same author

Aggregation-induced emission active seminaphthofluoresceins: a new class of xanthene luminogens for bioimaging.

Nanoscale·2026
Same author

Dendritic Polyglycerol Sulfate Reduces Inflammation Through Inhibition of the HMGB1/RAGE Axis in RAW 264.7 Macrophages.

International journal of molecular sciences·2025
Same author

Soft nanoparticles incorporating a benzo[<i>c</i>]xanthene fluorophore: facile synthesis and ratiometric pH sensing.

Journal of materials chemistry. B·2025
Same author

Luminescent insulin-Au(III) conjugate retains insulin biological properties in human microglia.

Nanoscale·2025
Same author

Charged dendrimers reduce glioblastoma viability by modulating lysosomal activity and HMGB1-RAGE interaction.

Biochemical pharmacology·2025

Related Experiment Video

Updated: May 28, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Metalloestrogenic effects of quantum dots.

Manasi P Jain1, Farida Vaisheva, Dusica Maysinger

  • 1Department of Pharmacology & Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, QC, H3G 1Y6, Canada.

Nanomedicine (London, England)
|October 21, 2011
PubMed
Summary

Cadmium telluride quantum dots (QDs) exhibit metalloestrogenic effects, promoting cell proliferation and uterine growth in mice. These endocrine-disrupting effects, mediated via estrogen receptors, can surpass those of 17β-estradiol.

More Related Videos

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Related Experiment Videos

Last Updated: May 28, 2026

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Area of Science:

  • Nanotechnology
  • Endocrinology
  • Toxicology

Background:

  • Quantum dots (QDs) are nanomaterials with diverse applications.
  • Cadmium-containing QDs raise concerns regarding potential toxicity and endocrine disruption.
  • Understanding the metalloestrogenic potential of QDs is crucial for risk assessment.

Purpose of the Study:

  • To investigate the metalloestrogenic effects of cadmium telluride (CdTe) quantum dots (QDs).
  • To compare QD-induced estrogenicity with 17β-estradiol and ionic cadmium.
  • To assess QD effects in human breast cancer cells and in vivo mouse models.

Main Methods:

  • Utilized MCF-7 human breast cancer cells to study estrogen-related signaling pathways.
  • Administered CdTe QDs to female prepubescent and ovariectomized adult mice.
  • Assessed cellular proliferation, estrogen receptor activation, and uterine changes.

Main Results:

  • In vitro, CdTe QDs induced cell proliferation, estrogen receptor α activation, and AKT/ERK phosphorylation, similar to 17β-estradiol.
  • Green QDs showed a stronger estrogenic response than orange QDs.
  • In vivo, QD treatment significantly increased uterine weight in mice.

Conclusions:

  • Cadmium-containing QDs act as endocrine disruptors, mediated through estrogen receptors.
  • QD-induced estrogenic effects can be more potent than 17β-estradiol or ionic cadmium.
  • These findings highlight the need for careful evaluation of nanomaterial safety.