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P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas
Lee-Wen Huang1, Chin-Cheng Lee
1Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Journal of Clinical Pathology
|October 21, 2011
Summary
p16 protein overexpression predicts lymph node metastasis and poorer survival in cervical cancer patients. Immunohistochemistry for p16 is valuable for treatment planning.
Area of Science:
- Oncology
- Cell Biology
Background:
- p16(INK4A) protein (p16) is a cyclin-dependent kinase inhibitor.
- p16 arrests the cell cycle in the G1 phase.
Purpose of the Study:
- To evaluate p16 as a predictive marker for lymph node metastasis.
- To assess p16's role in cervical carcinoma prognosis.
Main Methods:
- Studied 145 patients with FIGO stage I-IV cervical carcinoma.
- Immunohistochemistry on tissue microarrays assessed p16 expression.
- 95 patients underwent lymph node dissection.
Main Results:
- p16 overexpression observed in 74.5% of invasive carcinomas.
- Significant correlation between p16 expression and lymph node metastasis (p=0.007).
- p16 overexpression linked to poorer 5-year survival (59.3% vs 83.8%, p=0.015).
Conclusions:
- p16 expression is a significant predictor of lymph node metastasis in cervical cancer.
- p16 overexpression indicates a poor prognosis.
- Immunohistochemical p16 evaluation aids cervical cancer treatment planning.
