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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
High disaccharide intake associates with atherogenic lipoprotein profile
Emily Sonestedt1, Elisabet Wirfält, Peter Wallström
1Department of Clinical Sciences - Malmö, Lund University, SE-205 02 Malmö, Sweden. emily.sonestedt@med.lu.se
The British Journal of Nutrition
|October 21, 2011
Summary
A higher intake of disaccharides is linked to an atherogenic lipoprotein phenotype (ALP), characterized by small LDL particles. Improving ALP may involve reducing disaccharides and moderating protein and alcohol consumption.
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Lipid Metabolism
Background:
- Increased small LDL particles define an atherogenic lipoprotein phenotype (ALP).
- ALP is associated with elevated triglycerides (TAG) and reduced HDL-cholesterol.
- Previous studies identified ALP using principal component analysis in the Malmö Diet and Cancer (MDC) cohort.
Purpose of the Study:
- To investigate the relationship between macronutrient intake and the principal component representing ALP.
- To analyze dietary patterns associated with an atherogenic lipoprotein phenotype.
Main Methods:
- Analysis of 4301 healthy subjects from the MDC cohort (ages 46-68, 60% women).
- Dietary data collected via a modified diet history method.
- Plasma lipoprotein subfractions measured using high-resolution ion mobility.
Main Results:
- The principal component for ALP showed a significant positive association with disaccharide intake.
- ALP was inversely related to protein and alcohol consumption (P < 0.001).
Conclusions:
- Dietary disaccharide intake is a significant factor associated with the atherogenic lipoprotein phenotype.
- Reducing disaccharide intake and moderating protein and alcohol consumption may improve ALP.
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