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Related Experiment Video

Updated: May 28, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

A targeted strategy to wipe out Clostridium difficile.

Robert Orenstein¹, Kimberly C Aronhalt, James E McManus

¹Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA. orenstein.robert@mayo.edu

Infection Control and Hospital Epidemiology

|October 21, 2011

Summary

This summary is machine-generated.

Daily germicidal bleach wipe cleaning significantly reduced hospital-acquired Clostridium difficile infection (CDI) by 85%. This intervention also extended the time between infection cases, improving patient safety in healthcare settings.

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Area of Science:

Infectious Disease Epidemiology
Hospital Infection Control
Environmental Hygiene

Background:

High incidence of hospital-acquired Clostridium difficile infection (CDI) poses a significant challenge in healthcare settings.
Effective infection control strategies are crucial to reduce the burden of healthcare-associated infections.

Purpose of the Study:

To evaluate the efficacy of daily cleaning with germicidal bleach wipes in reducing hospital-acquired CDI.
To assess the impact of enhanced environmental disinfection on CDI transmission dynamics.

Main Methods:

Implementation of daily cleaning protocols using germicidal bleach wipes on hospital wards.
Monitoring and comparison of hospital-acquired CDI incidence rates before and after the intervention.
Analysis of the time interval between consecutive CDI cases.

Main Results:

A substantial 85% reduction in hospital-acquired CDI incidence was observed.
CDI incidence decreased from 24.2 to 3.6 cases per 10,000 patient-days.
The median time between CDI cases significantly increased from 8 to 80 days.

Conclusions:

Daily disinfection with germicidal bleach wipes is a highly effective strategy for controlling hospital-acquired CDI.
Enhanced environmental cleaning protocols can substantially decrease infection rates and improve patient safety.
This intervention demonstrates a significant positive impact on reducing the transmission of Clostridium difficile.