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Updated: May 28, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Multiple intracranial cavernomas with focal amyloid deposition - diagnostic pitfalls
1University Medical Center Maribor, Maribor, Slovenia, Institute of Neurology, Medical University of Vienna, Vienna, Austria, Institute of Pathology, Faculty of Medicine, Ljubljana, and University Medical Center, Ljubljana, Slovenia. tvelnar@hotmail.com
Diagnosing intracranial tumors can be challenging. Initial biopsies suggested amyloidomas, but further investigation revealed vascular lesions, likely cavernomas, highlighting the need for comprehensive diagnostic approaches.
Area of Science:
- Neuropathology
- Neuroradiology
- Neurosurgery
Background:
- Multiple intracranial calcified tumorous lesions present a diagnostic challenge.
- Focal amyloid deposition can mimic other pathologies.
Observation:
- Initial neuronavigated needle biopsy suggested amyloidomas.
- A second biopsy and advanced neuroimaging were performed.
Findings:
- The lesions were ultimately diagnosed as vascular in origin, likely cavernomas.
- Initial assessment based on a single biopsy was misleading.
Implications:
- This case underscores the limitations of relying on a single diagnostic tool.
- Comprehensive neuroimaging and repeat biopsies are crucial for accurate diagnosis of intracranial lesions.
- Accurate diagnosis is essential for appropriate treatment planning of brain tumors.
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