Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

Serum Studies: Renal Function Tests

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...

Renal Clearance

Renal Clearance

The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Current Status of Angiotensin Receptor Blocker Recalls.

Hypertension (Dallas, Tex. : 1979)·2019

Same author

Asymmetric dimethylarginine, erythropoietin resistance, and anemia in CKD.

Annals of translational medicine·2019

Same author

Testing two (of several) intravenous iron dosing strategies in hemodialysis.

Annals of translational medicine·2019

Same author

Antidiabetic medication use in patients with type 2 diabetes and chronic kidney disease.

Journal of diabetes and its complications·2019

Same author

Modification of eGFR-Based CKD Definitions: Perfect, or Enemy of the Good?

Journal of the American Society of Nephrology : JASN·2019

Same author

Effects of Selonsertib in Patients with Diabetic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2019

Search research articles

Related Experiment Video

Updated: May 28, 2026

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Validity of surrogate measures for functional nephron mass.

Jane C Tan¹, Jane Paik, Glenn M Chertow

¹Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. jane.tan@stanford.edu

Transplantation

|October 21, 2011

Summary

Estimating kidney nephron mass is crucial for transplant success. Body surface area (BSA) better predicts renal cortical volume than body mass index (BMI), though new models require further validation.

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Related Experiment Videos

Last Updated: May 28, 2026

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Radiology
Transplantation

Background:

Accurate assessment of transplanted nephron mass is vital for long-term allograft survival but challenging before organ retrieval.
Advanced radiologic imaging offers improved methods for determining total kidney and cortical volumes.

Purpose of the Study:

To characterize total kidney and cortical volumes using imaging data from living donor candidates.
To evaluate anthropomorphic surrogates for predicting nephron mass.
To develop and compare models for predicting renal cortical volume.

Main Methods:

Magnetic resonance or computed tomography imaging was used to reconstruct volume measurements.
Total kidney (n=312) and cortical volumes (n=236) were analyzed.
Cortical volumes were correlated with sex, age, weight, height, body mass index (BMI), and body surface area (BSA).

Main Results:

Mean cortical volume was 204 mL, with no significant difference between left and right kidneys.
Cortical volumes showed strong associations with sex and BSA, but not with weight, height, or BMI.
BSA was found to be a superior predictor of renal cortical volume compared to BMI.

Conclusions:

Body surface area (BSA) is a more effective surrogate than body mass index (BMI) for predicting renal cortical volume.
A statistically superior proxy for cortical volume was developed.
Further evaluation in larger populations is needed to confirm improvements in predictive accuracy.