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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Vaccinations01:51

Vaccinations

Overview

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Related Experiment Video

Updated: May 28, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Vaccination strategies in atherosclerosis.

S C A de Jager1, J Kuiper

  • 1Dept. of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands. s.de.jager@lacdr.leidenuniv.nl

Thrombosis and Haemostasis
|October 21, 2011
PubMed
Summary

Developing atherosclerosis vaccines is crucial for prevention, as current treatments are insufficient. This review explores antibody-based and immune-modulation strategies for effective atherosclerosis vaccination.

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Last Updated: May 28, 2026

Quantification of Atherosclerosis in Mice
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Published on: February 20, 2019

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Vaccine Development

Background:

  • Current atherosclerosis treatments (lipid lowering, anti-inflammatory) do not fully inhibit lesion progression.
  • Vaccination, a strategy successful in other diseases, offers potential for atherosclerosis prevention by eliciting specific immune responses.
  • Challenges in atherosclerosis vaccination include identifying suitable antigens and understanding immune responses.

Purpose of the Study:

  • To review current antibody-associated vaccination strategies for atherosclerosis.
  • To explore promising immune-modulation approaches for clinical application in atherosclerosis prevention.
  • To highlight the importance of developing atherosclerosis-specific vaccines.

Main Methods:

  • Review of existing literature on atherosclerosis vaccination strategies.
  • Analysis of antigen selection for active and passive immunization.
  • Evaluation of immune tolerance induction mechanisms.

Main Results:

  • Vaccination strategies have targeted lipid-antigens, inflammation-derived antigens, and cell-based approaches.
  • Cardiovascular side-effects of infection-based vaccines warrant attention.
  • Immune-modulation strategies show promise for clinical translation.

Conclusions:

  • Atherosclerosis-specific vaccination is vital for future prevention.
  • Further research into antigen selection and immune modulation is needed for effective vaccine development.
  • Successful vaccination could provide lifelong protection against atherosclerosis.