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Updated: May 28, 2026
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Validation of 24-hour flucytosine MIC determination by comparison with 48-hour determination by the Clinical and
Shawn R Lockhart1, Carol B Bolden, Naureen Iqbal
1Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA. gyi2@cdc.gov
Abstract:
Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only. Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.
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