Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Tension

Tension

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...

Tension

Tension

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...

Stress

Stress

When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...

General State of Stress

General State of Stress

The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...

Types of Stressors

Types of Stressors

A stressor is any event, condition, or stimulus that triggers stress and causes a physical or psychological response in the body. Stressors can be categorized into three main types: catastrophes; significant life changes; and daily hassles, including social stress. Each can be detrimental to physical and mental well-being.
Catastrophes
Catastrophes refer to large-scale, unpredictable events that create overwhelming stress and a sense of threat. Examples include natural disasters like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Active biosynthesis of gold nanoparticles mediated by obligate methylotrophic bacteria <i>Methylophilus</i> sp.

Frontiers in microbiology·2026

Same author

Zenflow spring system for benign prostatic hyperplasia - 24 month outcomes of the ZEST pilot studies.

Prostate cancer and prostatic diseases·2026

Same author

CT Hounsfield Unit Measurements Around the Hip and Their Utility for Opportunistic Screening: A Systematic Review.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2026

Same author

Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets.

Nature communications·2026

Same author

tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration.

bioRxiv : the preprint server for biology·2026

Same author

tRNA-derived fragments elevated in Alzheimer's disease facilitate Tau aggregation.

bioRxiv : the preprint server for biology·2026

Same journal

Corrigendum: Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Genes & development·2026

Same journal

A new perspective on ATR's role in translesion synthesis.

Genes & development·2026

Same journal

Mechanisms coordinating exit from the stem cell state in mammals.

Genes & development·2026

Same journal

Evolutionarily conserved spliceosome-exosome pathway in nuclear mRNA surveillance.

Genes & development·2026

Same journal

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.

Genes & development·2026

Same journal

Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR.

Genes & development·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

Stress puts TIA on TOP.

Pavel Ivanov¹, Nancy Kedersha, Paul Anderson

¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Genes & Development

|October 21, 2011

Summary

This summary is machine-generated.

Eukaryotic cells slow growth to survive nutrient scarcity by regulating protein expression. Stress granule proteins TIA-1 and TIAR control specific messenger RNAs (mRNAs) with 5'-terminal oligopyrimidine tracts (5'TOPs) during cellular stress.

More Related Videos

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

Related Experiment Videos

Last Updated: May 28, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Eukaryotic cells modulate protein expression for survival under nutrient limitation, a process linked to stress granules.
Stress granules are cytoplasmic foci where untranslated messenger ribonucleoprotein complexes (mRNPs) assemble during cellular stress.
The regulation of specific messenger RNAs (mRNAs) within stress granules is crucial for cellular adaptation.

Purpose of the Study:

To investigate the mechanistic insights into the regulation of 5'-terminal oligopyrimidine tract (5'TOP) mRNAs.
To elucidate the role of stress granule proteins TIA-1 and TIAR in controlling 5'TOP mRNA fate.
To understand how these proteins contribute to cellular survival under nutrient-limited conditions.

Main Methods:

Analysis of mRNA regulation within stress granules.
Biochemical assays to study protein-RNA interactions.
Investigating the function of TIA-1 and TIAR proteins.

Main Results:

TIA-1 and TIAR proteins are involved in the regulation of a specific subset of mRNAs.
These mRNAs contain 5'-terminal oligopyrimidine tracts (5'TOPs).
Mechanistic insights into how TIA-1 and TIAR interact with and regulate these specific mRNAs were provided.

Conclusions:

Stress granule proteins TIA-1 and TIAR play a key role in regulating 5'TOP mRNAs.
This regulation contributes to the cellular reprogramming that enhances survival under nutrient stress.
The study provides a deeper understanding of stress granule function in eukaryotic cells.