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The use of plerixafor in harvesting autologous stem cells in the pediatric setting

Kim Vettenranta1, Merja Möttönen, Pekka Riikonen

  • 1Division of Pediatric Hematology-Oncology, University of Tampere, Tampere, Finland. kim.vettenranta@pshp.fi

Pediatric Blood & Cancer
|October 21, 2011
PubMed

Insights

Plerixafor can help mobilize stem cells in heavily pretreated pediatric patients when standard chemotherapy and G-CSF fail. This approach shows promise for improving stem cell collection in challenging pediatric cases.

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Stem Cell Transplantation

Background:

  • Standard stem cell mobilization using chemotherapy and G-CSF is not always effective in heavily pretreated patients.
  • Plerixafor (AMD3100) is an established option for stem cell mobilization in adults.
  • Limited data exists on the efficacy and safety of plerixafor in pediatric populations.

Observation:

  • This study reports on the use of plerixafor in eight pediatric patients.
  • Plerixafor was administered either as an add-on to chemotherapy plus G-CSF or for stem cell remobilization.
  • The patients included were heavily pretreated, suggesting a need for alternative mobilization strategies.

Findings:

  • Plerixafor facilitated stem cell mobilization in pediatric cases where standard methods were insufficient.
  • The use of plerixafor, as an adjunct or for remobilization, demonstrated potential in achieving adequate stem cell yields.
  • Successful stem cell collection was observed in the reported pediatric cohort.

Implications:

  • Plerixafor represents a viable therapeutic option for enhancing stem cell mobilization in pediatric patients with difficult-to-mobilize stem cells.
  • Further research is warranted to establish optimal dosing and protocols for plerixafor in pediatric stem cell transplantation.
  • Expanding the use of plerixafor may improve outcomes for pediatric patients requiring autologous stem cell transplantation.

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