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Published on: March 30, 2019
Microarray meta-analysis defines global angiogenesis-related gene expression signatures in human carcinomas
Mario Anders1, Marion Fehlker, Qing Wang
1Department of Interdisciplinary Endoscopy, University Hospital Hamburg Eppendorf, Hamburg, Germany. m.anders@uke.uni-hamburg.de
Molecular Carcinogenesis
|October 21, 2011
Summary
This study identifies global gene expression signatures linked to angiogenesis in carcinomas. It reveals that down-regulation of angiogenesis genes may be a central aspect of tumor development.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Angiogenesis is crucial for cancer progression, involving complex gene networks.
- Identifying deregulated angiogenesis genes in carcinomas is essential for understanding cancer development.
Purpose of the Study:
- To identify angiogenesis genes deregulated in various carcinomas using meta-profiling.
- To define global gene expression signatures associated with angiogenesis in cancer.
Main Methods:
- Meta-profiling analysis of 15 published gene expression microarray studies (789 tumor, 190 healthy samples).
- Analysis of approximately 1,000,000 gene expression measurements for 480 angiogenesis-related genes.
- Validation using own microarray and quantitative RT-PCR data from colorectal carcinoma cohort.
Main Results:
- Identified a 25-gene signature with frequent down-regulation across 10 cancer types, independent of cancer entity.
- Characterized an additional 25-gene signature with frequent up-regulation.
- Both signatures accurately discriminated cancers from healthy tissues in cross-validation and own cohort data.
Conclusions:
- This study defines the first global gene expression signatures linked to angiogenesis in carcinomas.
- Gene down-regulation appears to be a significant factor in tumor angiogenesis.
- These signatures offer potential biomarkers for cancer detection and understanding angiogenesis.
