Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic control of cell communication in C. elegans development.

E M Maine1, J Kimble

  • 1Department of Biology, Syracuse University, NY 13214.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 1, 1990
PubMed
Summary

Cell communication guides nematode development. The glp-1 and lin-12 genes are key players, showing structural and functional relationships in Caenorhabditis elegans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.

Oncogene·2012
Same author

Sex Determination in Caenorhabditis elegans.

Journal of nematology·2009
Same author

Patient-controlled sedation for colonoscopy: a randomized trial comparing patient-controlled administration of propofol and alfentanil with physician-administered midazolam and pethidine.

Endoscopy·2003
Same author

PUF proteins and 3'UTR regulation in the Caenorhabditis elegans germ line.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

RNAi As a tool for understanding germline development in Caenorhabditis elegans: uses and cautions.

Developmental biology·2002
Same author

Posttravel hepatitis A: probable acquisition from an asymptomatic adopted child.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001

Area of Science:

  • Developmental biology
  • Genetics
  • Cell biology

Background:

  • Cell communication is essential for growth and differentiation in Caenorhabditis elegans development.
  • The genes glp-1 and lin-12 are known to mediate critical cell-cell interactions.
  • Understanding these interactions is key to deciphering developmental processes.

Purpose of the Study:

  • To analyze the genetic and molecular characteristics of glp-1 and lin-12.
  • To investigate the structural and functional relationships between glp-1 and lin-12.
  • To identify other genes that interact with glp-1 and/or lin-12.

Main Methods:

  • Genetic analysis of Caenorhabditis elegans.
  • Molecular analysis of gene function.
  • Comparative genomics and interaction studies.

Related Experiment Videos

Main Results:

  • glp-1 and lin-12 genes are structurally and functionally related.
  • These genes play crucial roles in mediating cell-cell interactions during development.
  • Identification of additional interacting genes provides a broader network view.

Conclusions:

  • The glp-1 and lin-12 genes are homologous and functionally conserved.
  • These genes are central components of signaling pathways regulating cell communication in C. elegans.
  • Further research on interacting genes will elucidate complex developmental mechanisms.