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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue encephalitis.

Kapil Borawake¹, Parikshit Prayag, Atul Wagh

¹Department of Critical Care Medicine, Shree Medical Foundation, Pune, Maharashtra, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine

|October 21, 2011

Summary

This case study highlights dengue encephalitis, a rare condition confirmed by dengue antibodies and antigen in cerebrospinal fluid. Characteristic brain imaging revealed thalamic involvement and hemorrhage, underscoring the importance of considering dengue in encephalitis cases.

Keywords:

Bilateral thalamic involvement dengue encephalitis dengue fever

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Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Dengue fever is a mosquito-borne viral illness, commonly causing febrile illness.
Encephalopathy is a known complication of dengue infection, but primary dengue encephalitis is rare.
Dengue virus is not typically considered a neurotropic virus.

Observation:

A patient presented with symptoms suggestive of encephalitis.
Diagnostic tests confirmed dengue infection, including serum antibodies and dengue antigen in cerebrospinal fluid.
Magnetic resonance imaging (MRI) of the brain showed characteristic findings, particularly bilateral thalamic involvement with hemorrhage.

Findings:

The case was confirmed as dengue encephalitis, despite initial considerations of other etiological possibilities.
Cerebrospinal fluid analysis revealed the presence of dengue antigen.
Brain MRI demonstrated specific lesions in the thalami with associated bleeding.

Implications:

This case emphasizes the need to consider dengue encephalitis in the differential diagnosis of unexplained encephalitis.
Accurate diagnosis of dengue encephalitis is crucial for appropriate patient management and outcomes.
Further research may elucidate the mechanisms of dengue neuroinvasion and encephalitis.