Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-mediated killing: effector mechanisms and mediators.

D M Ojcius1, J D Young

  • 1Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021.

Cancer Cells (Cold Spring Harbor, N.Y. : 1989)
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.

Cell death and differentiation·2026
Same author

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.

International journal of obesity (2005)·2017
Same author

Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections.

Mucosal immunology·2016
Same author

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection.

Journal of dental research·2015
Same author

Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells.

Molecular oral microbiology·2010
Same author

Inflammasomes bridge signaling between pathogen identification and the immune response.

Drugs of today (Barcelona, Spain : 1998)·2009
Same journal

Epithelial cell plasticity in neoplasia.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

Uptake of low-density lipoprotein by malignant cells--possible therapeutic applications.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

Some thoughts on the cytolytic mechanism of natural killer lymphocytes.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

A role for cholinesterases in tumorigenesis?

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
Same journal

The soluble interleukin-2 receptor as a marker for human neoplasia and immune status.

Cancer cells (Cold Spring Harbor, N.Y. : 1989)·1991
See all related articles

Cytolytic T lymphocytes and natural killer cells kill target cells using perforin or programmed cell death. High interleukin-2 levels may favor perforin use in infections and cancer.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Cytolytic T lymphocytes (CTLs) and natural killer (NK) cells are crucial for immune surveillance.
  • These cells employ distinct mechanisms to eliminate target cells.

Purpose of the Study:

  • To elucidate the mechanisms of target cell lysis mediated by immune effector cells.
  • To investigate the factors influencing the choice between perforin-mediated killing and programmed cell death pathways.

Main Methods:

  • The study reviews existing literature and experimental findings on immune cell-mediated cytotoxicity.
  • Analysis of conditions associated with perforin exocytosis and programmed cell death induction.

Main Results:

  • Perforin, a pore-forming protein, disrupts the target cell membrane, causing lysis.

Related Experiment Videos

  • Programmed cell death involves specific DNA fragmentation within target cells.
  • Perforin-mediated killing is suggested to occur in high interleukin-2 environments, such as in cancer and viral infections.

    • Conclusions:

    • The precise triggers for distinct cytotoxic mechanisms remain incompletely understood.
    • Further research is needed to fully elucidate the role of programmed cell death pathways in immune responses.