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Related Concept Videos

Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
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Related Experiment Video

Updated: May 28, 2026

Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
14:13

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Hormesis pervasiveness and its potential implications for pharmaceutical research and development.

Kenneth I Maynard1

  • 1Sanofi US, Inc.

Dose-Response : a Publication of International Hormesis Society
|October 21, 2011
PubMed
Summary

Hormesis, a dose-response phenomenon, is prevalent beyond traditional toxicology, impacting diverse fields like neuroscience and oncology. Recognizing hormesis can help overcome drug discovery and development challenges.

Keywords:
dose responsedrug developmentdrug discoveryhormesispharmaceutical industryresearch and development

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Area of Science:

  • Biochemistry
  • Radiation Biology
  • Toxicology
  • Neuroscience
  • Cardiology
  • Oncology

Background:

  • Hormesis is traditionally recognized in biochemistry, radiation biology, and toxicology.
  • Emerging evidence indicates hormesis extends to broader biomedical and clinical fields.

Purpose of the Study:

  • To review the widespread presence of hormesis across various scientific and medical disciplines.
  • To propose strategies for integrating hormesis into drug discovery and development.

Main Methods:

  • Literature review of published scientific studies.
  • Discussion of advanced technologies like high-throughput screening and adaptive trial design.

Main Results:

  • Hormesis is demonstrated to be a common biological phenomenon across diverse fields.
  • The review highlights the potential of hormesis in addressing drug development challenges.

Conclusions:

  • Acknowledging hormesis can enhance understanding of biological responses to stimuli.
  • Integrating hormesis principles may improve drug efficacy and safety, aiding the pharmaceutical industry.