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Updated: May 28, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
[Palmar-plantar erythrodysaesthesia syndrome local cold prevention]
María Paz Serrano Fernández1, María Jesús Gutiérrez Vilella, Angeles Pérez Martín-Palanco
1Servicio de Dermatología del Hospital Universitario 12 de Octubre.
Objective:
to evaluate the role of local cold applied to the tips on the prevention of palmar-plantar erythrodysaesthesia (PPE) caused by pegylated liposomal doxorubicin (PLD).
Materials And Methods:
from may 2006 to june 2009, 8 patients with cutaneous T-cell lymphoma mycosis fungoides type were treated with PLD. The median age was 56 years and was administered a total of 63 cycle, with an average of 7.87 cycle per person, with a dose of PLD 20 mg/m2 every 2 weeks. All patients had premedication with dexamethasone, ondasetron and pyridoxine. At the time all were given prophylaxis with local cold for an hour
Results:
only one patient had grade 4 PPE (12.5%), which appeared after the first cycle, subsequent can manage a total of 10. In absolute terms was recorded EPP grade 4 only 1.58% of cycles administered (1/63). In the remaining patients there was no degree of EPP.
Conclusions:
this paper demonstrates the effectiveness of several preventive measures (pyridoxine, corticosteroid and local cold) in the prevention of the PPE.
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