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Updated: May 28, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
Reversing age-related decline in working memory
Andrew R Mendelsohn1, James W Larrick
1Panorama Research Institute and Regenerative Sciences Institute, Sunnyvale, California, USA. amend@regensci.org
Abstract:
Higher cognitive functions, such as working memory and the ability to focus attention, decline as people age. Recently, it has been reported that decline in working memory in aging rhesus monkeys correlates with the loss of activity of a specific set of neurons in the prefrontal cortex during a delay following a learning cue. The activity of these neurons can be rescued by stimulating α-2 adrenergic receptors, inhibiting cyclic adenosine monophosphate (cAMP) signaling, or closing potassium channels that are known to inhibit firing and synaptic connectivity. Agents that stimulate neurons expressing α-2 adrenergic receptors may prove useful in treating working memory loss in humans.
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