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[Morphological changes caused by the dermonecrosis factor of the causative agents of cholera and various other
Abstract:
Intra- or subepithelial focal purulent inflammation with necrosis of exudating leucocytes during 1-2 days is developed in consequence of intradermal injection of the living cholera vibrios, cultured on membrane agar, or their supernatants. Sometimes coagulative necrosis of cover epithelium arises without preliminary purulent inflammation stage from the very beginning. Intradermal injection of living cholera vibrios leads to the development of coagulative necrotic foci in derma too. The vascular genesis of alterations mentioned above is supposed.
Insights
Intradermal injection of cholera vibrios causes focal inflammation and necrosis in skin. These changes, potentially vascular in origin, occur rapidly after exposure to live bacteria or their byproducts.
Area of Science:
- Microbiology
- Pathology
- Dermatology
Background:
- Cholera vibrios are known pathogens.
- The early skin response to cholera vibrios is not fully understood.
Purpose of the Study:
- To investigate the immediate pathological changes in the skin following intradermal injection of cholera vibrios.
Main Methods:
- Intradermal injection of living Vibrio cholerae or their supernatants in a model.
- Histopathological examination of skin tissue at 1-2 days post-injection.
Main Results:
- Focal purulent inflammation with leukocyte necrosis observed within 1-2 days.
- Coagulative necrosis of the epithelium occurred, sometimes without prior inflammation.
- Necrotic foci also developed in the dermis following injection of live cholera vibrios.
Conclusions:
- Intradermal cholera vibrios induce rapid inflammatory and necrotic skin responses.
- The observed alterations suggest a potential vascular genesis in the pathogenesis.