Related Experiment Video
Updated: May 28, 2026

Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation
Published on: April 19, 2024
Repetitive magnetic stimulation of the phrenic nerves for diaphragm conditioning: a normative study of feasibility
Dan Adler1, Stewart B Gottfried, Nathalie Bautin
1Service de Pneumologie et Réanimation et Centre de Neurostimulation Respiratoire, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Abstract:
Electrical stimulation can enhance muscle function. We applied repetitive cervical magnetic phrenic stimulation (rCMS) to induce diaphragm contractions in 7 healthy subjects (800 ms trains; transdiaphragmatic pressure (Pdi) measurements; tolerance ratings). Each rCMS train produced a sustained diaphragm contraction. Sixty-five percent of the maximal available output at 15 Hz proved the best compromise between Pdi and discomfort with nonfatiguing contractions. rCMS appears feasible and should be investigated for diaphragm conditioning in appropriate clinical populations.

