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Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799
Yoshihide Matsuo1, Kaneo Kanoh, Jae-Hyuk Jang
1Suntory Holdings Ltd. , Yamazaki, Shimamoto, Mishima, Osaka 618-0001, Japan.
Abstract:
A new catechol-type siderophore, streptobactin (1), was isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. YM5-799. The structure of streptobactin was determined by NMR and MS analyses and ESIMS/MS experiments to be a cyclic trimer of benarthin. A dibenarthin (2), a tribenarthin (3), and benarthin (4) were also obtained. The production of 1 was regulated by an iron concentration in the culture. The iron-chelating activity of the compounds was evaluated by the chrome azurol sulfonate assay.
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