Squeezing into differentiation
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Updated: May 28, 2026

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
Published on: March 8, 2019
1Lab for Sensory Development, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan. raj-ladher@cdb.riken.jp
Abstract:
The earliest steps in tooth development depend on signaling interactions that result in the condensation of mandibular mesenchyme into the tooth bud. Reporting in this issue of Developmental Cell, Mammoto et al. (2011) find that chemotactic signals coordinate condensation and that the compressive force generated is sufficient to induce tooth bud gene expression.
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