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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study
Alpna Chauhan1, Ashika Sequeria, Cathann Manderson
1Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Autonomic Neuroscience : Basic & Clinical
|October 22, 2011
Summary
Cancer cachexia is linked to autonomic nervous system (ANS) dysfunction. Patients show reduced heart rate variability (HRV), indicating impaired sympathetic and parasympathetic function.
Area of Science:
- Oncology
- Autonomic Neuroscience
- Physiology
Background:
- Autonomic nervous system (ANS) abnormalities are implicated in cachexia.
- Cancer cachexia is a complex syndrome characterized by involuntary weight loss.
Purpose of the Study:
- To investigate autonomic nervous system (ANS) function in cancer cachexia.
- To compare heart rate variability (HRV) and related biomarkers between cancer patients with weight loss and healthy controls.
Main Methods:
- Assessed heart rate variability (HRV) components in nine cancer patients and nine healthy volunteers.
- Measured serum cortisol and urinary catecholamines/metanephrines in both groups.
Main Results:
- Cancer patients demonstrated a significant global reduction in HRV parameters, including high frequency, low frequency, and total power, compared to controls.
- No significant differences were observed in serum cortisol or urinary catecholamine/metanephrine levels between the groups.
Conclusions:
- The findings suggest autonomic nervous system (ANS) dysfunction in cancer cachexia.
- This dysfunction involves a reduction in both sympathetic and parasympathetic components of the ANS.
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