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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 28, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study.

Alpna Chauhan1, Ashika Sequeria, Cathann Manderson

  • 1Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.

Autonomic Neuroscience : Basic & Clinical
|October 22, 2011
PubMed
Summary

Cancer cachexia is linked to autonomic nervous system (ANS) dysfunction. Patients show reduced heart rate variability (HRV), indicating impaired sympathetic and parasympathetic function.

Related Experiment Videos

Last Updated: May 28, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Oncology
  • Autonomic Neuroscience
  • Physiology

Background:

  • Autonomic nervous system (ANS) abnormalities are implicated in cachexia.
  • Cancer cachexia is a complex syndrome characterized by involuntary weight loss.

Purpose of the Study:

  • To investigate autonomic nervous system (ANS) function in cancer cachexia.
  • To compare heart rate variability (HRV) and related biomarkers between cancer patients with weight loss and healthy controls.

Main Methods:

  • Assessed heart rate variability (HRV) components in nine cancer patients and nine healthy volunteers.
  • Measured serum cortisol and urinary catecholamines/metanephrines in both groups.

Main Results:

  • Cancer patients demonstrated a significant global reduction in HRV parameters, including high frequency, low frequency, and total power, compared to controls.
  • No significant differences were observed in serum cortisol or urinary catecholamine/metanephrine levels between the groups.

Conclusions:

  • The findings suggest autonomic nervous system (ANS) dysfunction in cancer cachexia.
  • This dysfunction involves a reduction in both sympathetic and parasympathetic components of the ANS.