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Related Concept Videos

Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Overview of Connective Tissues Proper01:25

Overview of Connective Tissues Proper

Connective tissue proper is a class of connective tissue that encompasses all mature connective tissues except bone, cartilage, blood, and lymph. This extensive class of tissues has two subclasses — loose and dense connective tissues — classified based on the protein fiber arrangement and the amount of ground substance. 
The loose connective tissues have a meshwork of thin collagen and elastin fibers, which provide tensile strength for support and enough elasticity to move cells. They have...
Classification of Connective Tissues01:30

Classification of Connective Tissues

The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense.
Introduction to Connective Tissues01:11

Introduction to Connective Tissues

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Connective Tissue Fibers and Ground Substance01:17

Connective Tissue Fibers and Ground Substance

One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and water.

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Related Experiment Video

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Connective tissue nevi: an entity revisited.

Anne Saussine1, Karine Marrou, Phillippe Delanoé

  • 1Department of Pediatric Dermatology, Hôpital Necker-Enfants Malades (AP-HP), Paris, France.

Journal of the American Academy of Dermatology
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Connective tissue nevi (CTN) present a wide clinical spectrum, from mild papules to severe plaques. Histopathology is diverse, including a newly identified "cellular CTN" variant with increased fibroblasts.

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Area of Science:

  • Dermatology
  • Pathology
  • Genetics

Background:

  • Connective tissue nevi (CTN) are benign hamartomas with variable presentations, ranging from isolated to syndromic forms like Buschke-Ollendorff syndrome.
  • Limited literature exists on the diverse clinical and histopathologic manifestations of CTN.

Purpose of the Study:

  • To characterize the clinical and histopathologic features of connective tissue nevi.
  • To illustrate the spectrum of clinical disease associated with CTN.

Main Methods:

  • Retrospective study of 33 patients with confirmed CTN diagnoses.
  • Clinical assessment and histopathologic examination of lesional biopsy specimens.

Main Results:

  • Average age of onset for CTN was 2 years.
  • Three clinical forms identified: single-site (A), multi-site (B), and severe infiltration with functional impairment (C).
  • Histopathology revealed collagenomas (10), elastoma (1), mixed CTN (18), and a novel 'cellular CTN' variant (4) with increased fibroblasts; no clinical-histopathologic correlation was found.

Conclusions:

  • CTN exhibit a broad clinical spectrum, from isolated papules to severe, limb-affecting plaques.
  • Histopathologic findings are heterogeneous, encompassing a newly described 'cellular CTN' variant.
  • This study highlights the variability in CTN presentation and pathology.