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Updated: May 28, 2026
Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata
Tran Thi Hong Hanh1, Dan Thi Thuy Hang, Chau Van Minh
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
Objective:
To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata (C. odorata).
Methods:
The compounds isolated from the aerial parts of C. odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.
Results:
Six fatty acids (S)-coriolic acid (1), (S)-coriolic acid methyl ester (2), (S)-15,16-didehydrocoriolic acid (3), (S)-15,16-didehydrocoriolic acid methyl ester (4), linoleamide (5) and linolenamide (6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition. Compound 2 was the most active with the IC(50) values of 5.22 and 5.73 μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.
Conclusions:
The fatty acid components in C. odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care.
