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Related Experiment Video

Updated: May 28, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Perioperative allergy: risk factors.

C Caffarelli¹, G Stringari, G B Pajno

¹Department of Pediatrics, University of Parma, Parma, Italy. carlo.caffarelli@unipr.it

International Journal of Immunopathology and Pharmacology

|October 22, 2011

Summary

Patients with a history of unexplained reactions during anesthesia face a higher risk of perioperative allergic reactions. Previous safe exposure does not guarantee future safety from drug or latex allergies.

Related Experiment Videos

Last Updated: May 28, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Area of Science:

Anesthesiology
Immunology
Allergy

Background:

Perioperative anaphylactic and anaphylactoid reactions can be triggered by various agents including drugs, diagnostic agents, antiseptics, disinfectants, and latex.
Allergic reactions can occur without apparent risk factors, and a history of safe exposure to a product does not preclude future reactions.

Purpose of the Study:

To systematically review patient history characteristics and clinical parameters influencing the risk of developing perioperative allergic reactions.
To identify predictive factors for anaphylaxis during anesthesia.

Main Methods:

Systematic review of literature.
Analysis of patient history and clinical parameters associated with perioperative allergic reactions.

Main Results:

Patients with a prior unexplained reaction during anesthesia are at increased risk for subsequent perioperative allergic reactions.
Previous exposure to a related agent increases the risk of an allergic reaction to a specific culprit agent.
Multiple surgeries, occupational latex exposure, and fruit allergies are linked to higher frequencies of latex allergy.
Atopic patients and females may experience allergic perioperative reactions more frequently.

Conclusions:

A history of unexplained reactions during anesthesia is a significant risk factor for future perioperative allergic reactions.
Identifying specific risk factors, such as previous reactions and exposures, is crucial for preventing perioperative anaphylaxis.