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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Allergic Reactions02:06

Allergic Reactions

Overview
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...

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Related Experiment Video

Updated: May 28, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery
05:39

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Perioperative allergy: uncommon agents.

S Caimmi1, D Caimmi, F Cardinale

  • 1Department of Pediatrics, University of Pavia, Italy. sissi_del_78@hotmail.com

International Journal of Immunopathology and Pharmacology
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Anesthesia can trigger allergic reactions (anaphylaxis) from various agents. Patients with a history of anesthesia allergy require specialist evaluation and detailed reporting for future safety.

Related Experiment Videos

Last Updated: May 28, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery
05:39

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Medicine

Background:

  • Anaphylaxis during anesthesia is a significant risk for anesthesiologists.
  • Numerous agents, including neuromuscular blocking agents, latex, and antibiotics, can cause reactions.
  • Many other substances, such as NSAIDs and contrast media, are also implicated.

Purpose of the Study:

  • To review potential causes of anaphylaxis during anesthesia.
  • To discuss the role of preoperative screening and specialist evaluation.
  • To emphasize patient information and reporting for future anesthetic procedures.

Main Methods:

  • Literature review of reported anaphylactic reactions during anesthesia.
  • Analysis of common and less common allergenic agents.
  • Discussion of current recommendations for patient management.

Main Results:

  • Neuromuscular blocking agents, latex, and antibiotics are frequent culprits.
  • Hypnotics, opioids, local anesthetics, NSAIDs, ICM, and others are also implicated.
  • No universal premedication prevents reactions; specialist evaluation is key for at-risk patients.

Conclusions:

  • Anaphylaxis is a serious concern in anesthesia, with diverse potential triggers.
  • Systematic preoperative screening is not universally indicated, but specialist consultation is vital for allergic patients.
  • Informing patients and providing detailed reports are crucial for managing future anesthetic risks.