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Abnormal lipoprotein composition in normolipidemic diabetic patients
M Iwai1, G Yoshino, M Matsushita
1Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Diabetes Care
|July 1, 1990
Summary
Diabetic patients without hyperlipidemia show elevated lipoprotein abnormalities. Specifically, increased low-density lipoprotein (LDL) particle number and depleted cholesterol in LDL particles were observed.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Lipid Metabolism
Background:
- Diabetes mellitus is associated with dyslipidemia.
- Lipoprotein abnormalities may exist in diabetic patients even without overt hyperlipidemia.
Purpose of the Study:
- To investigate lipoprotein composition in normolipidemic diabetic patients.
- To identify potential subclinical lipoprotein abnormalities in diabetes.
Main Methods:
- Examined lipoprotein composition in 75 normolipidemic diabetic patients and healthy controls.
- Plasma cholesterol (chol) and triglyceride (TG) levels were strictly controlled.
- Measured total apolipoprotein B (apoB) and cholesterol-apoB ratios in various lipoprotein fractions.
Main Results:
- Plasma total chol and TG, LDL-chol, and HDL-chol were similar between diabetic and control groups.
- Total apoB was significantly elevated in diabetic subjects.
- Diabetic subjects showed increased LDL particle number (elevated LDL-apoB) and cholesterol-depleted LDL particles (suppressed chol-apoB ratio in LDL).
Conclusions:
- Normolipidemic diabetic patients exhibit distinct lipoprotein abnormalities.
- Increased LDL particle number and cholesterol depletion in LDL are characteristic of diabetes, independent of hyperlipidemia.
- These findings highlight the need for comprehensive lipid assessment in diabetic patients.