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Synthesis of a Forssman antigen derivative for use in a conjugate vaccine
Jianhao Feng1, Rachel Hevey, Chang-Chun Ling
1Alberta Ingenuity Center for Carbohydrate Science, Department of Chemistry, University of Calgary, Calgary AB, Canada T2N 1N4.
Abstract:
The total chemical synthesis of a Forssman antigen analog is described. The pentasaccharide contains a functionalized tether which should facilitate future conjugation with immunogenic proteins. We found that the total synthesis can be efficiently achieved by following a convergent 2+3 strategy, and using N-Troc protected GalNAc thioglycoside as a donor.
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