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Related Experiment Videos

LSD.

K Kulig1

  • 1Section of Emergency Medicine and Trauma, University of Colorado Health Sciences Center, Denver.

Emergency Medicine Clinics of North America
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Lysergic acid diethylamide (LSD) is a street drug. Emergency physicians can diagnose acute LSD intoxication by recognizing its typical symptoms, such as visual disturbances and dilated pupils, even when drug history is unknown.

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Area of Science:

  • Emergency Medicine
  • Toxicology
  • Psychopharmacology

Background:

  • Lysergic acid diethylamide (LSD) remains prevalent as a street drug in the United States.
  • Emergency physicians may encounter patients with acute LSD intoxication, often with limited or unavailable patient history.
  • Accurate diagnosis is crucial for appropriate patient management in emergency settings.

Purpose of the Study:

  • To outline the characteristic clinical presentation of acute LSD intoxication.
  • To discuss diagnostic challenges, particularly in cases with co-ingestions.
  • To highlight the utility of modern toxicology methods for LSD detection.

Main Methods:

  • Review of clinical signs and symptoms associated with LSD intoxication.
  • Discussion of differential diagnoses in acute drug toxicity.

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  • Mention of radioimmunoassay as a diagnostic tool.

    • Main Results:

    • Acute LSD intoxication typically presents with illusions of color and sound, a sense of "cosmic awareness," and massively dilated pupils.
    • True hallucinations are less common than perceptual distortions.
    • Diagnosis can be complicated by the presence of other substances, especially those inducing coma.

    Conclusions:

    • The clinical syndrome of LSD intoxication is recognizable, aiding emergency physicians in diagnosis.
    • Diagnostic difficulties may arise with polydrug use.
    • Radioimmunoassay provides a reliable method for detecting LSD in toxicological analyses.