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Related Experiment Video

Updated: May 28, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Response to anti-angiogenesis: an ever changing feature.

Francesco Bertolini¹

¹Laboratory of Hematology-Oncology, Department of Pathology, European Institute of Oncology, 20141 Milan, Italy. francesco.bertolini@ieo.it

Breast (Edinburgh, Scotland)

|October 22, 2011

Summary

New anti-angiogenic drugs show promise for cancer therapy, but clinical benefits are limited. Future research should explore resistance mechanisms and identify new vascular targets beyond VEGF.

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Isolation and Culture Expansion of Tumor-specific Endothelial Cells

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Area of Science:

Oncology
Pharmacology
Molecular Biology

Background:

Anti-angiogenic drugs are approved for various advanced cancers, including breast, lung, colorectal, kidney, and CNS cancers.
Despite approvals, the clinical benefit of current anti-angiogenic therapies remains limited.

Purpose of the Study:

To review and discuss rational developments for a new generation of anti-angiogenic drugs.
To explore strategies for improving the efficacy of anti-angiogenic cancer therapies.

Main Methods:

Literature review focusing on current anti-angiogenic drug mechanisms and clinical outcomes.
Analysis of resistance and escape mechanisms associated with anti-VEGF therapies.
Identification of potential complementary vascular targets for novel anti-angiogenic drug development.

Main Results:

Current anti-angiogenic drugs primarily target Vascular Endothelial Growth Factor (VEGF) and its pathways.
Understanding resistance to anti-VEGF therapy is crucial for advancing treatment.
Identifying novel vascular targets is essential for developing next-generation anti-angiogenic drugs.

Conclusions:

Further research is needed to overcome limitations of current anti-angiogenic therapies.
Elucidating resistance mechanisms to anti-VEGF agents is a key area for investigation.
Discovering and validating complementary vascular targets will enable the development of more effective anti-angiogenic drugs.