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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
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Published on: May 15, 2013

Bronchial hyperresponsiveness decreases through childhood.

Amund Riiser1, Vegard Hovland, Petter Mowinckel

  • 1Oslo University Hospital, Department of Paediatrics, Oslo, Norway. amund.riiser@uus.no

Respiratory Medicine
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Bronchial hyperresponsiveness (BHR) generally decreases in severity during adolescence. Most children maintained their BHR category, with few experiencing increased BHR between ages 10 and 16.

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Published on: April 13, 2010

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Adolescent Health

Background:

  • Limited understanding of bronchial hyperresponsiveness (BHR) development during adolescence.
  • Assessing changes and identifying risk factors for BHR in this age group is crucial.

Purpose of the Study:

  • To evaluate the changes in bronchial hyperresponsiveness (BHR) from age 10 to 16.
  • To identify significant risk factors associated with BHR persistence or development during adolescence.

Main Methods:

  • Longitudinal study of 517 subjects from a Norwegian birth cohort.
  • Clinical examinations, interviews, and methacholine challenges at ages 10 and 16.
  • Logistic regression analysis to determine risk factors for BHR categories.

Main Results:

  • Overall decrease in BHR severity from age 10 to 16 (33% to 15% with PD(20) ≤ 8).
  • Majority (57%) remained in their BHR category; 82% of those who changed showed decreased severity.
  • BHR ≤ 8 at age 10 was a strong predictor (OR 6.3) of BHR at age 16, independent of other factors.

Conclusions:

  • Bronchial hyperresponsiveness tends to decrease in severity throughout adolescence.
  • BHR status is generally stable, with a minority experiencing increased BHR.
  • Early BHR severity is a key predictor of later BHR, unaffected by asthma or body size.