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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Lingo01:11

Genetic Lingo

Overview
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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Related Experiment Video

Updated: May 28, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Deafness in the genomics era.

A Eliot Shearer1, Michael S Hildebrand, Christina M Sloan

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA.

Hearing Research
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Genomic technologies have revolutionized the study of hereditary hearing loss. DNA sequencing advances accelerate gene discovery and improve genetic diagnosis for deafness.

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Last Updated: May 28, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
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Published on: May 10, 2019

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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

Area of Science:

  • Genetics
  • Otolaryngology
  • Genomic Medicine

Background:

  • Hereditary hearing loss is a significant health concern.
  • The discovery of the first human deafness gene marked a turning point.
  • Advances in DNA sequencing technology have accelerated research.

Purpose of the Study:

  • To review the impact of genomic technologies on deafness research.
  • To discuss the application of these technologies in clinical settings.
  • To highlight advancements in genetic diagnosis and gene discovery for hereditary hearing loss.

Main Methods:

  • Review of commonly used genomic technologies.
  • Analysis of the application of genomic technologies in genetic diagnosis.
  • Examination of genomic technology's role in discovering novel deafness genes.

Main Results:

  • Genomic technologies have significantly advanced the understanding of hereditary hearing loss.
  • These technologies are crucial for accurate genetic diagnosis.
  • Accelerated discovery of new genes associated with deafness.

Conclusions:

  • Genomic advancements have transformed both the research and clinical management of hereditary hearing loss.
  • Continued application of genomic technologies will further improve diagnosis and treatment.
  • The integration of genomics is essential for addressing deafness causes.