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Updated: May 28, 2026
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
DTI reveals network injury in perinatal stroke
Jeroen Dudink1, Serena J Counsell, Maarten H Lequin
1Department of Neonatology, Sophia Children's Hospital, Dr Molenwaterplein 60, Rotterdam 3015GJ, The Netherlands. j.dudink@erasmusmc.nl
Archives of Disease in Childhood. Fetal and Neonatal Edition
|October 22, 2011
Summary
Neonatal stroke causes acute network injury. Diffusion tensor imaging revealed altered diffusion measures in specific thalamic regions connected to the affected cortex.
Area of Science:
- Neuroimaging
- Pediatric Neurology
- Stroke Research
Background:
- Previous studies indicated pulvinar changes on diffusion-weighted imaging following extensive cortical injury in neonatal stroke.
- Understanding direct thalamic region involvement after cortical injury is crucial for neonatal stroke research.
Purpose of the Study:
- To investigate the direct impact of neonatal stroke on specific ipsilateral thalamic regions using diffusion tensor imaging (DTI).
- To assess alterations in diffusion parameters within thalamic nuclei connected to the primary cortical injury site.
Main Methods:
- Analysis of DTI images from three term infants with acute unilateral cortical arterial ischemic stroke.
- Utilized probabilistic tractography to delineate specific thalamic regions of interest (ROIs).
- Evaluated apparent diffusion coefficient (ADC) and three eigenvalues (EV) within the defined ROIs.
Main Results:
- Significantly lower ADC and EV values were observed in thalamic ROIs corresponding to the ischemic cortex.
- These changes were compared to the unaffected contralesional thalamic nuclei.
Conclusions:
- Findings support the concept of acute, specific network injury in neonatal stroke.
- Altered ADC and EV in distinct thalamic regions correlate with the cortical areas affected by the ischemic injury.
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