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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
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CD4+CD25highFoxP3+ regulatory T-cells in hematologic diseases.

Hee-Won Moon1, Bo Hyun Kim, Chul Min Park

  • 1Department of Laboratory Medicine, Konkuk University School of Medicine, Hospital, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, Korea.

The Korean Journal of Laboratory Medicine
|October 22, 2011
PubMed
Summary

Regulatory T-cells (Tregs) are elevated in AML and MDS compared to autoimmune diseases. Peripheral blood is a practical sample type for Treg measurement in routine hematologic diagnostics.

Keywords:
Bone marrowFoxP3Hematologic diseasePeripheral bloodRegulatory T-cells

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Generation of Induced Regulatory T Cells from Primary Human Na&iuml;ve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Regulatory T-cells (Tregs) are crucial for immune response regulation.
  • Investigating Treg status in neoplastic and autoimmune hematologic diseases is important.
  • Evaluating technical aspects of Treg measurement is necessary.

Purpose of the Study:

  • To compare Treg populations in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and autoimmune hematologic diseases.
  • To assess the practical utility of peripheral blood versus bone marrow for Treg analysis.
  • To identify key markers for Treg detection.

Main Methods:

  • Analysis of 68 subjects including AML, MDS, autoimmune diseases, and controls.
  • Flow cytometry used to analyze CD4+CD25+ Tregs.
  • Detection markers included CD4, CD25, and FoxP3 (forkhead box P3).
  • Samples analyzed from peripheral blood (PB) and bone marrow (BM).

Main Results:

  • Significant correlation found between CD4+CD25(high)/CD4 and CD4+CD25(high)FoxP3+/CD4 populations.
  • AML and high-risk MDS groups showed significantly larger Treg populations in PB compared to autoimmune and control groups.
  • Comparable Treg elevations were observed in BM.
  • Treg populations were significantly larger in PB than in BM.

Conclusions:

  • Provides comparative data on Tregs in AML, MDS, and autoimmune hematologic diseases.
  • Suggests peripheral blood is a practical sample type for routine Treg measurement.
  • Highlights the need for large-scale studies on the diagnostic role of Treg measurement.