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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Modality-specific axonal regeneration: toward selective regenerative neural interfaces.

Parisa Lotfi1, Kshitija Garde, Amit K Chouhan

  • 1Department of Bioengineering, University of Texas at Arlington Arlington, TX, USA.

Frontiers in Neuroengineering
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Neurotrophins like NGF and NT-3 can guide specific nerve fiber regeneration. This research shows potential for segregating sensory and motor axons for better prosthetic control.

Keywords:
NGFNT-3bionicsmultielectrode arraynerve regenerationneurotrophinsperipheral nervesensory feedback

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Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
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Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
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Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration

Published on: May 3, 2017

Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Peripheral nerve interfaces are crucial for prosthetic control but struggle with mixed nerve fiber types.
  • Selective recording and stimulation of specific nerve fibers remain challenging.

Purpose of the Study:

  • To investigate the use of type-specific neurotrophins to guide the regeneration of distinct axonal populations into separate compartments.
  • To assess the potential for segregating sensory and motor axons for improved neural interface applications.

Main Methods:

  • In vitro studies using compartmentalized diffusion of nerve growth factor (NGF) and neurotrophin-3 (NT-3) to guide dorsal root ganglion neuron regeneration.
  • Utilized a 3D "Y"-shaped in vitro assay to quantify axonal growth and branching.
  • In vivo experiments with transected adult rat sciatic nerves in a "Y"-shaped conduit filled with NGF or NT-3.

Main Results:

  • NGF significantly increased axon length (2.5-fold) in vitro, while NT-3 promoted branching (3-fold).
  • The in vitro "Y"-assay showed NGF increased unbranched axon length fivefold.
  • In vivo, CGRP+ pain fibers were attracted to the sural nerve, and N-52+ large-diameter axons were found in tibial/NT-3 compartments.

Conclusions:

  • Neurotrophic factors can effectively guide the enrichment of specific sensory axons into designated regenerative chambers.
  • This approach supports the use of neurotrophins for segregating sensory and potentially motor axons in peripheral nerve interfaces.
  • Demonstrates a promising strategy for enhancing the specificity of neural interfaces for prosthetic devices.