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Angiogenesis and melanoma - from basic science to clinical trials.

Maxine Sylvia Emmett, Daemon Dewing, Rowan Oliver Pritchard-Jones

American Journal of Cancer Research

|October 22, 2011

Summary

Anti-angiogenic therapies, targeting Vascular Endothelial Growth Factor (VEGF), offer new hope for metastatic malignant melanoma. While not yet revolutionary, ongoing trials explore their potential to improve outcomes and prevent metastasis.

Keywords:

Cancer VEGF angiogenesis anti-angiogenic therapy bevacizumab melanoma metastatic melanoma receptor tyrosine kinase inhibitors signal transduction inhibitors vascular endothelial growth factor

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Area of Science:

Oncology
Medical research

Background:

Malignant melanoma management traditionally relies on surgery, chemotherapy, and radiotherapy.
Anti-angiogenic agents represent a significant advancement, offering a fourth therapeutic modality.
Vascular Endothelial Growth Factor (VEGF) is a key target in developing these novel therapies.

Purpose of the Study:

To review the current status and rationale of clinical trials involving anti-angiogenic therapies for metastatic malignant melanoma.
To assess the outcomes of key clinical trials and understand their impact on melanoma care.
To explore future directions for optimizing anti-angiogenic therapy in melanoma treatment.

Main Methods:

Review of preclinical studies demonstrating the efficacy of anti-angiogenic agents.
Analysis of clinical trial data for anti-angiogenic therapies in metastatic melanoma.
Examination of combination therapies involving anti-VEGF agents and established treatments.

Main Results:

Preclinical research generated significant enthusiasm for anti-angiogenic agents.
Clinical trials combining anti-VEGF therapies with other treatments show some promise for metastatic melanoma.
Current anti-angiogenic therapies have not yet revolutionized melanoma care as anticipated.

Conclusions:

Anti-angiogenic therapies, particularly targeting VEGF, hold potential in managing metastatic malignant melanoma.
Further research and optimized targeting strategies are necessary to enhance the efficacy of these agents.
Combination therapies and trials aimed at metastasis prevention are crucial for future advancements.