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Published on: November 1, 2014
[Experimental model of histamine-induced anaphylactoid reaction on beagle dogs]
Zhiguo Wang1, Danqiao Wang, Youhua Yu
1Experimental Research Center, China Academy of Chinese Medical Scinces, Beijing 100700, China. zhgw68_8@tom.com
Objective:
To establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.
Method:
Anaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.
Result:
It showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.
Conclusion:
Intravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.
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