Related Experiment Video
Updated: May 28, 2026
18:57
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
[Drug interactions on P-glycoprotein transport level and its application]
1Capital Medical University School of Traditional Chinese Medicine, Beijing 100069, China.
Summary
Drug interactions involving P-glycoprotein (an efflux transporter) can alter drug concentrations. Understanding these interactions between herbal and western medicines is crucial for safe and effective clinical use.
Area of Science:
- Pharmacology
- Biochemistry
- Drug Metabolism
Background:
- P-glycoprotein is a key efflux transporter protein found in various tissues.
- It significantly influences drug distribution and concentration in plasma and tissues.
- P-glycoprotein plays a critical role in numerous drug-drug interactions.
Purpose of the Study:
- To discuss potential drug interactions mediated by P-glycoprotein.
- To highlight the impact of P-glycoprotein on the efficacy and safety of combined herbal and western medications.
Main Methods:
- Review of scientific literature on P-glycoprotein function.
- Analysis of mechanisms by which herbal and western drugs interact with P-glycoprotein.
Main Results:
- P-glycoprotein can induce or inhibit drug transport.
- Interactions may lead to enhanced drug efficacy or adverse effects.
- Altered drug concentrations in plasma and tissues are a consequence of P-glycoprotein activity.
Conclusions:
- Rational use of herbal and western drugs requires understanding P-glycoprotein-mediated interactions.
- Clinical drug use can be optimized by considering P-glycoprotein's role in drug disposition.
Related Concept Videos
01:25Pharmacokinetics: Drug–Drug Interactions
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
01:16Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
01:30Drug toxicity: Drug–Drug Interaction
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
01:26Pharmacokinetics: Drug–Food and Drug–Viral Interactions
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
01:06Carrier-Mediated Transport
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
01:27Nonlinear Pharmacokinetics: Role of Transporters
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
Polymorphisms occurring in drug transporters can alter...