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Updated: May 28, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
[Preparation and characterization of niosomes of Semen Strychni alkaloids extract]
Jie Hu1, Zhenzhen Wu, Kefei Hu
1Institute of Beijing Increase Biological Products, Beijing 102209, China.
Objective:
To prepare a noisome formulation of Semen Strychni alkaloids extract with high encapsulation efficiency.
Method:
S. Strychni alkaloids were encapsulated into niosomes by pH gradient loading method. The factors influencing on the encapsulation efficiency were investigated, and formulation and preparation process of niosomes were optimised and validated.
Result:
When the drug to lipid weight ratio was under 1: 10, pH gradient in buffer solution of citric acid at 50 degrees C was more than 4.0, the niosomes (mean diameter 179.2 nm and Zeta potential -25.41 mV) were formed with encapsulation efficiency of over 86.9%.
Conclusion:
The pH gradient loading method was reliable for preparing niosomes of Semen Strychni alkaloids extract.
