Related Experiment Video
Updated: May 28, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
Published on: July 7, 2023
Latent structure of unipolar and bipolar mood symptoms
Anthony O Ahmed1, Bradley A Green, Charles B Clark
1Department of Psychiatry and Health Behavior, Georgia Health Sciences University, 997 Saint Sebastian WayAugusta, GA 30912, USA. aahmed@georgiahealth.edu
Objectives:
The taxonic versus dimensional status of mood symptoms has been the subject of debate among mental health professionals. Conventional diagnostic models suggest that mood disorders are categorical; however, the inability of categorical models to adequately account for subthreshold unipolar and bipolar presentations and the heterotypic continuity of symptoms in unipolar and bipolar cases has resulted in growing support for dimensional views. The current study sought to evaluate the relative viabilities of categorical and dimensional models of mood symptoms within a taxometric framework.
Methods:
We examined the latent structure of mood symptoms in an epidemiological sample drawn from the Collaborative Psychiatric Epidemiological Surveys. Using three taxometric procedures (MAMBAC, MAXEIG, and L-Mode), we analyzed indicators of mania and depression created from the mood symptoms section of the survey.
Results:
The taxometric analyses supported a taxonic rather than dimensional structure for mania and depression. Membership in the mania and depressive taxa was associated with meeting criteria for DSM-IV lifetime manic episode and major depressive disorder, respectively. We identified a subset of 700 individuals falling into both taxa; membership in this subset was associated with lifetime bipolar disorder status. Group membership predicted designated external variables including help-seeking, family history, and duration of impairment. Within taxon and/or complement groups, severity scores still appeared to predict external variables.
Conclusion:
Our findings suggest that although taxonic, mood disorders possess meaningful dimensional variation.
More Related Videos
Related Concept Videos
Bipolar Disorder
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview
Mania and Antimanic Drugs: Overview
Borderline Personality Disorder
Genetic and Environmental Contributions
Borderline Personality...
