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Updated: May 28, 2026

Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
LC-MALDI-TOF imaging MS: a new approach in combining chromatography and mass spectrometry of copolymers
Steffen M Weidner1, Jana Falkenhagen
1Federal Institute for Materials Research and Testing (BAM), D-12489 Berlin, Richard-Willstaetter-Strasse 11, Germany. steffen.weidner@bam.de
Abstract:
A new approach that utilizes MALDI-TOF imaging mass spectrometry as a new detector for polymer chromatography is presented. For the first time, the individual retention behavior of single structural units of polyethylene oxide (PEO)/polypropylene oxide (PPO) copolymers and changes of the copolymer composition could be monitored. Composition specific calibration curves could be easily obtained by displaying the copolymer ion intensity data. This approach provides completely new insights in the chromatographic principle of copolymer separation and could be used to easily modify and adapt conditions for separation. In combination with electrospray deposition, homogeneous sample/matrix traces of surprisingly high spatial resolution could be obtained.
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