Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormone interactions in the Sertoli cells.

A Steinberger, J Walther, J J Heindel

    In Vitro
    |January 1, 1979
    PubMed
    Summary

    This study shows how follicle-stimulating hormone (FSH) and testosterone affect rat Sertoli cells. Sertoli cells play a key role in mediating hormonal effects on sperm production.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Artificial Intelligence Clustering Approach for Force Mapping Analysis of Polyacrylic Acid (PAA)/Polyethylene Oxide (PEO) Polymer Brushes for Biosensor Applications.

    Journal of molecular recognition : JMR·2026
    Same author

    Variation in partial direct costs of dry cow therapy on 37 large dairy herds.

    JDS communications·2024
    Same author

    Variation in partial direct costs of treating clinical mastitis among 37 Wisconsin dairy farms.

    Journal of dairy science·2023
    Same author

    Quantification of antimicrobial usage in adult cows and preweaned calves on 40 large Wisconsin dairy farms using dose-based and mass-based metrics.

    Journal of dairy science·2021
    Same author

    Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis.

    Andrology·2016
    Same author

    Evolution of DOHaD: the impact of environmental health sciences.

    Journal of developmental origins of health and disease·2014

    Area of Science:

    • Reproductive Biology
    • Endocrinology
    • Cell Biology

    Background:

    • Sertoli cells are crucial for spermatogenesis, responding to hormonal signals.
    • Understanding Sertoli cell function is key to understanding male fertility.

    Purpose of the Study:

    • To investigate the in vitro effects of follicle-stimulating hormone (FSH) and testosterone on rat Sertoli cells.
    • To elucidate the mechanisms of hormonal action within Sertoli cells during sexual maturation.

    Main Methods:

    • Isolated rat Sertoli cell populations were used for in vitro studies.
    • FSH binding, cyclic AMP accumulation, androgen-binding protein (ABP) secretion, and androgen receptor presence were analyzed.

    Main Results:

    • Sertoli cells bind FSH and increase cyclic AMP and ABP secretion upon stimulation.
    • FSH binding and cyclic AMP response change with sexual maturation, with decreased cyclic AMP response despite increased FSH receptors.
    • Evidence for cytoplasmic and nuclear androgen receptors and their interaction with chromatin was found.

    Conclusions:

    • Sertoli cells mediate hormonal effects on spermatogenesis through FSH and testosterone signaling.
    • A model for hormonal interactions in the seminiferous tubule involving Sertoli cells was proposed.

    Related Experiment Videos