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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

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Introduction to the Human Microbiota

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The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
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Updated: May 28, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
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Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

Microbiome and malignancy.

Claudia S Plottel1, Martin J Blaser

  • 1Department of Medicine, New York University Langone Medical Center, New York University, New York, NY 10016, USA. claudia.plottel@nyumc.org

Cell Host & Microbe
|October 25, 2011
PubMed
Summary
This summary is machine-generated.

The human microbiome, comprising bacteria and other microbes, plays a crucial role in cancer development, influencing malignancy through local, distant, and viral interactions. Understanding these microbial-host interactions is key to explaining cancer disparities.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

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Related Experiment Videos

Last Updated: May 28, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

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Published on: October 23, 2021

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

Area of Science:

  • Oncology
  • Microbiology
  • Human Microbiome Research

Background:

  • Cancer development is not fully explained by genetics or environmental carcinogens alone.
  • The human microbiome, a complex community of microbes, is an emerging factor in cancer etiology.
  • Existing research highlights the need to explore microbial-host interactions in malignancy.

Purpose of the Study:

  • To review the principles and paradigms of microbiome-related malignancy.
  • To illustrate these principles through specific microbial-host interactions.
  • To synthesize current understanding of the microbiome's role in cancer development.

Main Methods:

  • Literature review of microbiome-related malignancy.
  • Analysis of three distinct microbial-host interaction models.
  • Discussion of local, distant (estrobolome), and viral mechanisms of microbiome influence.

Main Results:

  • The microbiota can affect local and adjacent neoplasia.
  • The estrobolome model explains distant effects of microbial metabolites.
  • Interactions with latent viruses contribute to malignancy.

Conclusions:

  • The human microbiome is integral to cancer development.
  • Microbial-host interactions are multifaceted, involving diverse microbial species.
  • Further research into the microbiome's role is essential for understanding and potentially preventing cancer.