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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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Skin Diseases and Disorders

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Updated: May 28, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Advances in atopic dermatitis.

Natalija Novak1, Donald Y M Leung

  • 1Department of Dermatology and Allergy, University of Bonn, Sigmund-Freud Str. 25, D-53105 Bonn, Germany.

Current Opinion in Immunology
|October 25, 2011
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) involves skin barrier defects and altered immune responses. Ongoing research aims to fully understand the complex mechanisms behind this common skin condition.

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

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Published on: September 27, 2017

Area of Science:

  • Immunodermatology
  • Skin barrier function
  • Atopic dermatitis pathogenesis

Background:

  • Atopic dermatitis (AD) is a common skin condition characterized by compromised skin barrier function.
  • Immune system dysregulation, involving both innate and adaptive immunity, plays a crucial role in AD.
  • The complex interplay of factors contributing to AD manifestation is still under investigation.

Purpose of the Study:

  • To elucidate the intricate mechanisms underlying atopic dermatitis.
  • To further understand the role of barrier defects and immune responses in AD.

Main Methods:

  • Review of recent research on atopic dermatitis pathophysiology.
  • Analysis of the interactions between immune systems and external/internal factors.

Main Results:

  • Atopic dermatitis arises from a combination of skin barrier defects.
  • Modified immune responses from both innate and adaptive systems contribute to AD.
  • The complete network of mechanisms causing AD is not yet fully elucidated.

Conclusions:

  • Atopic dermatitis is a multifactorial disease involving skin barrier and immune system abnormalities.
  • Further research is necessary to comprehensively understand the pathogenesis of AD.