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Updated: May 28, 2026

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Specific immunotherapy: beyond the clinical scores.

Giovanni Passalacqua¹

¹Allergy and Respiratory Diseases, University of Genoa, Italy. passalacqua@unige.it

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|October 25, 2011

Summary

Specific immunotherapy offers unique long-lasting benefits beyond symptom relief. These include carryover effects and asthma prevention, highlighting its sustained impact on immune responses to allergens.

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Area of Science:

Allergy and Immunology
Immunotherapy Mechanisms

Background:

Traditional evaluation of specific immunotherapy (SI) efficacy relies on clinical scores.
SI exhibits unique effects like carryover and prevention due to immune response modulation.
The literature on these additional effects requires thorough evaluation.

Purpose of the Study:

To review experimental data on the unique effects of specific immunotherapy.
To assess the carryover and preventive actions of SI.
To understand the implications of SI's complex mechanism of action.

Main Methods:

Comprehensive literature search of EmBase, Medline, and Scopus databases.
Inclusion of randomized, non-randomized, and placebo-controlled clinical trials of immunotherapy.
Systematic review of available experimental data.

Main Results:

Carryover effect is well-established for injection immunotherapy; less data exists for sublingual immunotherapy.
Evidence for SI preventing asthma onset is supported by two randomized studies for sublingual and one for subcutaneous routes.
Profound and persistent modifications in immune response to allergens are induced by SI.

Conclusions:

Long-lasting and preventive effects of SI should be considered in efficacy evaluations.
Further rigorous studies are needed to confirm these additional effects.
The unique benefits of SI may have significant socioeconomic implications.